Ignorance inevitably will be encountered in multidisciplinary, interdisciplinary, and transdisciplinary dialogues, scholarship, and research. This Handbook is a source of starting-points and benchmarks for such dialogues and collaborations. Its chapters provide both guidelines to and exemplars of key orienting strategies for understanding ignorance. This chapter reviews these strategies briefly, before continuing on to an overview of the Handbook and a survey of the possibilities opened up by its contributors. All of the chapters make substantial contributions to at least one of four fundamental issues: the varieties of ignorance, its construction, its uses, and its unmaking. The chapter consists of sections on each of these. It also briefly examines the many paths that ignorance studies may travel in the future.