In scientific discourse, as well as in public debates, scientists are often presented as charismatic prophets with a message for the people. My aim, in this article, is to explore the place of prophecy in today's politics of pandemic preparedness in the United States. How is the category of the unknown invoked in scientifically inspired prophetic proclamations? At stake in such an inquiry are the ways in which a prophetic existence is capacitated or incapacitated at the threshold of the known and the unknown. What does it take for the prophet's voice to be recognized as reasonable and accepted as authoritative? Charismatic personality and discursive authorization play significant roles, to be sure. But the efficacy of pandemic prophecy must also be situated in relation to the temporal sensibilities and anxieties to which they respond. What is the architecture of these sensibilities and anxieties?. © 2014 by The Wenner-Gren Foundation for Anthropological Research. All rights reserved.